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Histological evaluation took into account the presence of changes such as: 1) inflammatory response, 2) periportal hepatic congestion, with foci of hepatic necrosis, 3) hyaline sclerosis in renal arterioles and kidney degeneration (common in intense physically active), and 4) presence of changes in the thickness of walls and signs of hypertrophy of myocardial fibers. Side-effects can occur even if estrogen levels are kept under control.

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